A Method for Detecting Breakpoints in Array CGH data.

Abstract

In present, microarray CGH experiments became a powerful technique for analysing changes in DNA, by comparing control DNA and DNA of interest. This is widely used for example in genome cancer or species distinguishing studies. The method produce huge amount of data and special statistic techniques for detecting copy number changes regions are necessary. We propose a new method for detecting “breakpoints” in DNA. The performance of the method is demonstrated using publicly available data set.